Evidence map›Paper›PMID 41940186›Full record

ArticleBrain communications2026

Fibronectin type III domain-containing protein 5/irisin in extracellular vesicles is reduced in older individuals.

Tai R Hunter, Natalia M Lyra E Silva, Guilherme B de Freitas, Tayna Rody, Luis E Santos, Jieming Zhang, Alexis Bullock, Maria Carmela Tartaglia, Sheela Abraham, Chiara Nicolini and 4 more

Abstract read
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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tai R HunterDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada.ORCID https://orcid.org/0000-0003-4816-9457
Natalia M Lyra E SilvaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada.
Guilherme B de FreitasCentre for Neuroscience Studies, Queen's University, Kingston, ON K7L 2V5, Canada.
Tayna RodyInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ 21941-902, Brazil.
Luis E SantosD'OR Institute for Research and Education, Rua Diniz Cordeiro, Rio de Janeiro, RJ 22281-100, Brazil.ORCID https://orcid.org/0000-0002-0694-733X
Jieming ZhangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada.
Alexis BullockDepartment of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sheela AbrahamDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada.
Chiara NicoliniDepartment of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Aimee J NelsonDepartment of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Jennifer J HeiszDepartment of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Margaret FahnestockDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.
Fernanda G De FeliceDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada.ORCID https://orcid.org/0000-0001-8358-0589

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The progressive accumulation of physiological stress as we age, known as allostatic load, is linked to an increased risk of dementia. Fostering brain resilience through physical exercise can counteract allostatic load and improve adaptation to age-related brain alterations. Fibronectin type III domain-containing protein 5 (FNDC5)/irisin is a neuroprotective exercise-linked hormone found in extracellular vesicles (EV-FNDC5/irisin). Here, we sought to analyse EV-FNDC5/irisin in ageing as a promising biomarker of brain resilience. We measured exercise-associated factors, including EV-FNDC5/irisin, brain-derived neurotrophic factor (BDNF), and cathepsin B in the serum of 31 young (18-28 years) and 19 older subjects (65-79 years). Levels of FNDC5/irisin in serum-derived EVs are markedly reduced in older subjects compared to young (

Indexed as

ageingAlzheimer’s diseasebiomarkersexerciseexerkines

Identifiers

PMID41940186
PMCPMC13049368

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.