Evidence map›Paper›PMID 41940169›Full record

ArticleJournal of pharmaceutical analysis2026

MST4 as a key driver of osteoclast activation in osteoporosis.

Bin Zhang, Jiangjiang Zhang, Xuqiang Liu, Qiang Xu

Abstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bin ZhangDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China.
Jiangjiang ZhangDepartment of Orthopaedic Anaesthesia Operating Room, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China.
Xuqiang LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China.
Qiang XuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis, characterized by excessive bone resorption driven by heightened osteoclast activity, remains a major health concern with molecular mechanisms that are not fully understood. This study explores the role of mammalian Sterile 20-like kinase 4 (MST4), a member of the Sterile 20 (Ste20) kinase family, in osteoclast differentiation and function. Analysis of blood samples from osteoporosis patients revealed a significant increase in MST4 expression compared to healthy controls, with a negative correlation to bone mineral density (BMD).

Indexed as

AutoubiquitinationMST4Osteoclast differentiationOsteoporosisPhosphorylationTRAF6

Identifiers

PMID41940169
PMCPMC13049931

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.