Evidence map›Paper›PMID 41940158›Full record

ReviewaBIOTECH2026

Plant base editing: a decade of progress and future applications.

Ruixiang Zhang, Zhiye Zheng, Guangzhou Li, Xinglei Zheng, Liying Su, Xudong Yuan, Tie Li, Jiantao Tan, Dongchang Zeng, Shaocun Zhang and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in aBIOTECH, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruixiang ZhangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Zhiye ZhengGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Guangzhou LiGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Xinglei ZhengGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Liying SuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Xudong YuanGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Tie LiGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Jiantao TanRice Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Genetics and Breeding of High-Quality Rice in Southern China (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Rice Science and Technology, Guangdong Rice Engineering Laboratory, Guangzhou, 510640, China.
Dongchang ZengGuangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin, University Engineering Research Center of Bioinformation and Genetic Improvement of Specialty Crops, Guangxi Normal University, Guilin, 541006, China.
Shaocun ZhangSchool of Life Sciences, Institute for Immunology, State Key Laboratory of Membrane Biology, China Ministry of Education Key Laboratory of Protein Sciences, Tsinghua University, Beijing, 100084, China.
Jialin LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Haochun ShenGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Nan ChaiGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Yao-Guang LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.
Qinlong ZhuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Agriculture, College of Life Science, South China Agricultural University, Guangzhou, 510642, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Base editors derived from clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) systems are widely used for genomic studies in both plants and animals. The broad applicability and safety of base-editing approaches have garnered considerable attention from the research community, and there could be ways to further enhance targeting efficiency and target window range. However, the complex classification and diverse functionalities of base editors pose challenges to their effective utilization and improvement. In this review, we discuss technical principles characterizing various types of base editors, including cytosine base editors (CBEs), adenine base editors (ABEs), dual base editors (DBEs), thymine base editors (TBEs), and guanine base editors (GBEs), among others, which employ distinct mechanisms and DNA repair pathways. We also describe current optimization strategies to assist researchers in improving the deployment of these tools under specific conditions. Finally, we comprehensively analyze the practical applications and advantages of base editors, offering a clear view of their development, their previous and potential applications, and how to select the appropriate tools for specific purposes.

Indexed as

Base editing toolboxBase editorsPrecise genome editingProtein evolution in vivo

Identifiers

PMID41940158
PMCPMC12973408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.