ArticleClinical optometry2026
An Observational, Multicenter, Parallel-Cohort Study Evaluating the Association of Clinical Manifestations and Patient-Reported Outcomes in Patients with
Article in Clinical optometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to evaluate the clinical manifestations and patient-reported outcomes related to Patients and Methods: In this observational, multicenter, cross-sectional, parallel-cohort study conducted at 7 sites in the United States, adult participants were assigned to study cohorts based on collarette grade: Control Cohort (no collarettes), Cohort 1 (1-10 collarettes), or Cohort 2 (>10 collarettes). Key outcome measures included collarette grading, lid margin erythema, ocular symptoms (itching, fluctuating vision, irritation, redness, and burning) measured on a visual analog scale (VAS), and the location of ocular itching when present. Results: A total of 147 participants were enrolled and completed the study: 47 in the Control Cohort, 46 in Cohort 1, and 54 in Cohort 2 (a total of 100 participants with ≥1 collarette, identified as having Conclusion: This study demonstrated the vast majority (85%) of patients with
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