ReviewCurrent research in toxicology2026
An integration of physiological, morphological and biochemical assessments in studying guinea pig models of ototoxicity and otoprotection-a systematic review.
Review in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This systematic review aims to explore the development and utilization of a comprehensive test battery comprising physiological, morphological, and biochemical assessments in guinea pig models to study mechanisms of ototoxicity and otoprotection. Methods: This review was developed from peer-reviewed articles almost exclusively dealing with guinea pigs published in those journals listed on Journal Citation Reports. Results: Initially, 560 articles were retrieved from 1994 to 2024. Following the guidelines (PRISMA 2020 statement) for reporting reviews, 54 relevant papers were ultimately selected. Conclusion: Using animal models of ototoxicity and otoprotection, particularly the guinea pig can provide valuable insights into the mechanisms underlying ototoxicity and otoprotection in humans. This approach offers a detailed framework for elucidating ototoxic mechanisms and exploring therapeutic strategies for otoprotection, while also encouraging researchers to pursue basic research in this field.
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Registered trials
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