ArticleJournal of inflammation research2026
LncRNA TLR8-AS1 Restricts HIV-1 Infection and Inflammation in Macrophages by Suppressing Arachidonic Acid Metabolism Through NFAT1.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Long non-coding RNA (lncRNA) TLR8-AS1 has been implicated in immune regulation, but its role in HIV-1 infection remains unexplored. Methods: TLR8-AS1 expression was assessed in PBMCs and primary monocyte-derived macrophages (MDMs) from HIV-1/AIDS patients and healthy controls. Its subcellular localization was determined via bioinformatics, FISH, and nucleocytoplasmic fractionation. In THP-1-derived macrophages, the functional impact of TLR8-AS1 was evaluated using TLR8-AS1 overexpression and NFAT1-knockdown models; viral replication, inflammatory cytokines, and arachidonic acid (AA) metabolism were analyzed by qPCR, ELISA, and Western blot. Results: TLR8-AS1 expression levels were positively correlated with CD4 Conclusion: TLR8-AS1 restricts HIV-1-induced inflammation and viral replication through the NFAT1-AA axis. These findings identify TLR8-AS1 as a potential therapeutic target for mitigating chronic inflammation and viral persistence in HIV-1 infection.
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