Evidence map›Paper›PMID 41940019›Full record

ReviewFrontiers in physiology2026

Therapeutic potential of exerkines in neurodegenerative and mental disorders: a narrative review.

Suwol Yang, Hye-Won Sang, Seoyeon Kim, Eun-Jeong Cho, Youngju Choi, Dong Woo Kang, Young C Jang, Dong-Ho Park, Hyo-Bum Kwak, Jang Soo Yook

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Suwol YangDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Hye-Won SangDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Seoyeon KimDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Eun-Jeong ChoDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Youngju ChoiInstitute of Sports and Arts Convergence, Inha University, Incheon, Republic of Korea.
Dong Woo KangCollege of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Young C JangDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Dong-Ho ParkDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Hyo-Bum KwakDepartment of Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.
Jang Soo YookDivision of Humanities and Social Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative and mental disorders impose significant global disease burdens and pose serious social and economic challenges. Physical exercise (PE) exerts beneficial effects on brain health, contributing to a reduction in the risk of Alzheimer's disease (AD), Parkinson's disease (PD), depression, anxiety, and post-traumatic stress disorder (PTSD). To understand these effects of PE, a variety of molecules released from various tissues in response to PE have been discovered, which are collectively called 'exerkines'. In particular, the skeletal muscle acts as an endocrine organ, secreting exerkines and is included in the category of myokines that facilitate direct or indirect crosstalk between the muscle and the brain. Although muscles actively interact with organs such as the liver, pancreas, and adipose tissue, the precise mechanisms of muscle-brain communication have yet to be fully elucidated. In the skeletal muscle, the types of exerkines secreted and their effects vary depending on the PE modality. Furthermore, these exerkines can cross the blood-brain barrier (BBB) to exert direct effects or act indirectly

Indexed as

aerobic exerciseAlzheimer’s diseaseblood–brain barrierexerkinesmental disordersmuscle-brain crosstalkParkinson’s diseaseresistance exercise

Identifiers

PMID41940019
PMCPMC13043392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.