ReviewFrontiers in immunology2026
Regulation of B cell development and lymphocyte function by transcriptional coactivator OCA-B.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Targeted Degradation of KAT6A: Expanding the Therapeutic Frontier of Epigenetic Drug Discovery.ACS medicinal chemistry letters · 2026Article
- Targeted Degradation of CDK2: A New Strategy for Overcoming Cyclin E‑Driven Cancers.ACS medicinal chemistry letters · 2026Article
- Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer.ACS medicinal chemistry letters · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
OCA-B (OCT Coactivator from B cells) is highly expressed in B cells and is the first-identified tissue-specific transcriptional coactivator. Mechanistically, OCA-B is recruited to target genes through primary interactions with DNA-binding transcription factors OCT1/OCT2, as well as secondary interactions with MEF2B, and its effector functions in activating transcription involve interactions with the Mediator coactivator complex. Physiologically, OCA-B plays an essential role in antigen-stimulated Germinal Center (GC) formation and transcription of secondary immunoglobulin (Ig) genes. OCA-B also regulates bone marrow and peripheral B cell development. While GC B cell-specific inactivation of
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