ArticleFrontiers in immunology2026
A multi-epitope approach for development of a universal vaccine against leptospirosis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Computational systems immunology and multi-scale modeling for the design of a Multi-Epitope Vaccine (MEV) against emerging multidrug-resistant Klebsiella michiganensis.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Materials: To address this challenge, we employed comparative pan-genomic analysis and reverse vaccinology to identify conserved potential vaccine candidates (PVCs) and designed a multi-epitope vaccine (MEV) incorporating highly immunogenic B- and T-cell epitopes. Unlike previous studies largely limited to computational prediction or a small number of known antigens, our strategy integrates soft-core genome-wide antigen prioritization with structural validation and experimental evaluation of innate and adaptive immune responses. Selected epitopes were linked with appropriate spacers and fused to a TLR4 agonist (APPHALS) at the N-terminus to enhance immune activation. Results and discussion:
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Registered trials
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