ArticleNature reviews bioengineering2026
Mechanomedicine.
Article in Nature reviews bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization.Nucleus (Austin, Tex.) · 2026Review
- LIPUS-mediated mechanotransduction activates the YAP/TAZ/SCX axis and enhances tenogenesis-associated responses in tendon stem cells.Biomedical reports · 2026Article
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Micro/Nanorobots (MNRs) at the Intersection of Mechanobiology and Artificial Intelligence: An Emerging Frontier for Precision Nanomedicine.ACS nano medicine · 2026Review
- From biomechanical mechanisms to clinical reasoning: Deciphering mechanobiological drivers of aortic valve calcification for precision therapy.Mechanobiology in medicine · 2026Review
- Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Traction Force Microscopy for Viscoelastic Substrates: A Semi-Analytical Method.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bridging nanotechnology and mechanobiology.Nature nanotechnology · 2026Article
- Mechanobiological landscape of muscle stem cells.Skeletal muscle · 2026Review
- Mechanobiological research fueling the advancement of mechanotherapy and mechanohealth.Mechanobiology in medicine · 2026Article
- The cutting-edge advancements in biomaterials under the guidance of intelligence and bionics.Regenerative biomaterials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Mechanical forces act throughout the body across multiple scales, from organs and tissues to cells and molecules, playing a vital role in maintaining tissue integrity, regulating cellular functions and supporting physiological performance. Importantly, alterations in mechanical forces and properties can be hallmarks of tissue injury and disease, and can thus serve as valuable biomarkers for disease monitoring and diagnostics and can be harnessed to modulate biological processes for therapeutic benefit. This concept, termed mechanomedicine, offers an important strategy in disease diagnosis and therapy. In this Review, we first introduce biomechanics and mechanobiology as the underlying principles of mechanomedicine and outline the properties and measurements of key mechanical signatures in health and disease. We then explore the application of mechanomedicine across scales, from organ-level and tissue-level diagnostics to cellular and molecular mechanotherapeutics, including strategies for tissue regeneration and rehabilitation. Finally, we highlight challenges and opportunities in the clinical translation of mechanomedicine approaches, in particular with regards to the innovation of materials and devices, the manufacturing of cells and organoids, the definition and standardization of mechanical biomarkers, and the integration of artificial intelligence.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.