ArticleFrontiers in pharmacology2026
Effectiveness of a multifaceted intervention on reducing non-guideline-concordant prescribing of calcium and vitamin D analogues after total thyroidectomy.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative hypocalcemia is a common complication of total thyroidectomy. Due to a lack of standardized perioperative management protocols, there is often a wide variation in clinical practice, resulting in non-guideline conforming calcium and vitamin D analogue (NGC-CaVD) prescribing. This can lead to issues with patient safety and recovery. Objective To determine if a multi-faceted intervention could reduce NGC-CaVD after total thyroidectomy, assess safety outcomes, and identify factors associated with inappropriate prescribing. Methods: This retrospective observational cohort study included 629 adults undergoing total thyroidectomy (322 pre-intervention, 307 post-intervention). The intervention bundle included: (1) developing an institutional guideline, (2) conducting staff education, (3) pharmacist-led medication reviews with structured recommendations, (4) medication reconciliation, and (5) collaborative rounds. The primary outcome was the rate of NGC-CaVD. Safety outcomes included the incidence of symptomatic hypocalcemia and length of hospital stay. Results: The multifaceted intervention significantly reduced the overall NGC-CaVD rate from 45.96% in the pre-intervention group to 23.45% in the post-intervention group ( Conclusion: The implementation of a multi-faceted intervention improved guideline adherence for postoperative prescribing of calcium and vitamin D analogues without affecting symptomatic hypocalcemia and length of stay. Additionally, the model provides a framework for the standardization of post-thyroidectomy hypocalcemia management and the improved appropriateness of medication prescribing.
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