Evidence map›Paper›PMID 41939826›Full record

SynthesisFrontiers in pharmacology2026

Preclinical evidence of the therapeutic effect of

Saheed Olatunbosun Akiode, Adeoti Gbemisola Adeniran, Oyedayo Phillips Akano, Ayokunmi Stephen Olusa, Oghale Oghenefego Ovuakporie-Uvo, Oluchukwu Perpetual Okeke, Olunike Rebecca Abodunrin, Folahanmi Tomiwa Akinsolu, Uwaisu Iliyasu, Olajide Odunayo Sobande and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saheed Olatunbosun AkiodeBiotechnology Advanced Research Centre, Sheda Science and Technology Complex (SHESTCO), Garki, Nigeria.
Adeoti Gbemisola AdeniranDepartment of Physiology, University of Medical Sciences, Ondo City, Nigeria.
Oyedayo Phillips AkanoDepartment of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ago Iwoye, Ogun, Nigeria.
Ayokunmi Stephen OlusaDepartment of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Oghale Oghenefego Ovuakporie-UvoDepartment of Science Laboratory Technology/Centre for Herbal Medicine and Drug Discovery, University of Medical Sciences, Ondo City, Ondo State, Nigeria.
Oluchukwu Perpetual OkekeNigerian Institute of Medical Research Foundation, Yaba, Lagos State, Nigeria.
Olunike Rebecca AbodunrinDepartment of Epidemiology and Biostatics, Nanjing Medical University, Nanjing, China.
Folahanmi Tomiwa AkinsoluCenter for Reproduction and Population Studies, Clinical Sciences Department, Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria.
Uwaisu IliyasuDepartment of Pharmacognosy and Drug Development, Kaduna State University, Kaduna, Nigeria.
Olajide Odunayo SobandeNigerian Institute of Medical Research Foundation, Yaba, Lagos State, Nigeria.
Kamoru Abdulazeez AdeniyiDepartment of Animal and Environmental Biology, Federal University Dutse, Dutse, Jigawa State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peptic ulcer disease (PUD) remains a global health burden, with current therapies limited by recurrence, adverse effects, and high costs. Materials and Methods: We searched PubMed, CINAHL, Scopus, Web of Science, and the Cochrane Library from inception (without time filter) to August 2025. Eligible studies were randomized controlled animal experiments assessing Results: Eleven (11) studies involving 268 animals met the inclusion criteria, with SYRCLE quality scores ranging from 8 to 9. Pooled analysis showed that Conclusion: Systematic Review Registration: Identifier CRD420251080346.

Indexed as

anti-ulcergastric ulcergastroprotectivemeta-analysisMoringa oleiferapeptic ulcer diseasesystematic reviewulcer index

Identifiers

PMID41939826
PMCPMC13047084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.