ReviewAnnals of pediatric cardiology
Efficacy of thromboprophylaxis following stage II surgical palliation for single-ventricle physiology: A systematic review and meta-analysis.
Review in Annals of pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Postoperative thrombosis remains a significant cause of mortality and morbidity, especially in patients with single-ventricle physiology (SVP). The standard management plan for SVP consists of a three-stage surgical palliation, with widely varying thromboprophylaxis strategies. While routine thromboprophylaxis is standard after stages I and III, its role for stage II palliation remains controversial. This study aims to evaluate the impact of routine thromboprophylaxis in patients undergoing stage II palliation, with particular attention to cases involving pulmonary artery (PA) reconstruction, where the risk-to-benefit ratio of therapy may differ from routine stage II procedures. Methods and Results: Analyses were conducted across 15 studies published between 1981 and 2021 ( Conclusions: This study supports the use of routine thromboprophylaxis following second-stage palliation of SVP, particularly in patients undergoing PA reconstruction. However, the evidence is limited by observational study designs, heterogeneity among studies, and the lack of recent high-quality data. Further well-designed studies are warranted to confirm these findings and to identify the optimal antithrombotic agent.
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