ArticleCureus2026
A Complex Case of Glucose-Phosphate Isomerase Deficiency With an Indeterminate Adrenal Incidentaloma.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Adrenal incidentalomas are being identified more frequently with the widespread use of cross-sectional imaging, and their assessment requires careful evaluation to exclude hormonal excess and malignancy. We present the case of a middle-aged woman with chronic hemolytic anaemia due to glucose-phosphate isomerase (GPI) deficiency who was found to have a gradually enlarging left adrenal mass during long-term follow-up. Over an 11-year period, the lesion increased in size from 1.2 cm to 6 cm, appropriately raising concern about malignant potential. The presence of additional paravertebral soft-tissue lesions added further diagnostic uncertainty. Through a multidisciplinary approach involving endocrinology, haematology, specialist radiology, and regional multidisciplinary team discussion, supported by detailed biochemical assessment and positron emission tomography-computed tomography (PET-CT) imaging, the lesion was ultimately characterised as a biochemically non-functioning adrenal incidentaloma with low metabolic activity. This case underscores the value of multidisciplinary collaboration and highlights the importance of recognising extramedullary hematopoiesis as a potential radiological mimic of malignancy in patients with chronic hemolytic disorders.
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