ArticleFrontiers in oncology2026
Risk management in the dual crisis of unresectable colorectal cancer and deep vein thrombosis: navigating between hemorrhage and antithrombosis.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Patients with advanced, unresectable colorectal cancer in need of anticoagulation for deep vein thrombosis (DVT) with active or high-risk gastrointestinal bleeding (GIB) have a critical dilemma. Withholding anticoagulation has a risk of fatal thrombosis, while giving anticoagulation makes life-threatening bleeding worse. A retrievable inferior vena cava (IVC) filter may be a temporary stopgap while an active GIB is occurring. Once hemostasis has occurred, therapeutic anticoagulation should begin. Low molecular weight heparin (LMWH) is preferred over direct oral anticoagulants (DOAs) because of a lower risk of mucosal bleeding, and if necessary, apixaban is suggested. Dosing must be adjusted for thrombocytopenia. Management requires meticulous and individualized risk assessment. Future priorities include improved risk-prediction tools and targeted therapies to mitigate this precarious "therapeutic tightrope."
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