Evidence map›Paper›PMID 41939442›Full record

ArticleInternational journal of pharmaceutics: X2026

Metastable phase diagram, mobility, and kinetic stability of amorphous mixtures of two mutually compatible APIs.

Wahi Noor, Michela Romanini, Laia Villalobos, Bijori Talukder, Josep Lluís Tamarit, Roberto Macovez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wahi NoorGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.
Michela RomaniniGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.
Laia VillalobosGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.
Bijori TalukderGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.
Josep Lluís TamaritGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.
Roberto MacovezGrup de Caracterització de Materials, Departament de Física and Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), EEBE, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DSC, dielectric spectroscopy, and optical microscopy, are employed to analyze the equilibrium and out-of-equilibrium binary phase diagram of two antifungal azole compounds, fluconazole (FLZ) and econazole (ECZ), to study the physical stability of co-amorphous formulations that may allow co-administration and a faster dissolution of the poorly soluble ECZ compound. The two crystalline APIs form a eutectic equilibrium phase diagram with eutectic point at

Indexed as

Amorphous solid solutionsEutectic amorphous mixturesFormulation pre-developmentGlass transition temperaturePhysical stability of glassesRelaxation dynamics

Identifiers

PMID41939442
PMCPMC13049897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.