ArticleInternational journal of pharmaceutics: X2026
Hesperidin-loaded Eudragit S100 nanoparticles alleviate ulcerative colitis by repairing intestinal barrier and modulating gut microbiota.
Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A biomimetic chondrocyte membrane-camouflaged tFNA nanoplatform for reprogramming the cartilage-synovium axis in osteoarthritis.Materials today. Bio · 2026Article
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10 authors.
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Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with no curative therapy. Hesperidin (HDN) exhibits potent anti-inflammatory and antioxidant properties, but its poor solubility limits its therapeutic application. Here, we developed a colon-targeted nano-formulation by encapsulating HDN in pH-responsive Eudragit S100 nanoparticles (HDN-EUD NPs). The nanoparticles were optimized using Box-Behnken Design, yielding uniform spherical morphology with a mean particle size of 174.4 nm and encapsulation efficiency of 83.98%. HDN-EUD NPs remained stable in simulated gastric and intestinal fluids but rapidly disintegrated in simulated colonic fluid, releasing 74% of HDN within 2 h. At the cellular level, HDN-EUD NPs exhibited excellent biocompatibility and significantly enhanced protection against H₂O₂-induced oxidative stress and apoptosis.
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