Trial reportDrug design, development and therapy2026
Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Remimazolam versus Propofol in Renal Allograft Surgery: A Methodological Commentary [Letter].Drug design, development and therapy · 2026Article
- Hemodynamic Stability Beyond ED95 in Older Adults: Comment on Topical Airway Lidocaine Spray and Sufentanil for Tracheal Intubation [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Topical lidocaine is commonly used to blunt hemodynamic responses to laryngoscopy and intubation. In elderly patients, however, its specific effect on reducing the required dose of sufentanil during induction remains unquantified. We aimed to determine whether pre-intubation lidocaine spray lowers the 95% effective dose (ED Patients and Methods: Eighty patients aged 65-80 years undergoing elective surgery under general anesthesia with tracheal intubation were enrolled in this randomized, double-blind, dose-finding study. Prior to intubation, patients were randomly assigned to receive an oropharyngeal and laryngeal spray of either 2% lidocaine (Group A) or normal saline (Group B). The induction dose of sufentanil for each subsequent patient was adjusted based on the previous patient's hemodynamic response, following a biased-coin up-and-down sequential allocation method with a step size of 0.05 µg·kg Results: The estimated ED Conclusion: In elderly patients, topical airway lidocaine spray reduces the ED
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