Evidence map›Paper›PMID 41939401›Full record

ArticleACS omega2026

Dimeric Anthraquinone Rugulosin A Induces Apoptosis in Lung Adenocarcinoma and Targets PI3K/AKT/MAPK Pathways

Joe Anthony H Manzano, Elian Angelo M Abellanosa, Jose Paolo P Aguilar, Simone Brogi, Chia-Hung Yen, Kin Israel Notarte, Nicanor Austriaco, Allan Patrick G Macabeo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joe Anthony H ManzanoThe Graduate School, University of Santo Tomas, 1015 España, Manila, Philippines.
Elian Angelo M AbellanosaResearch Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., Manila 1015, Philippines.ORCID https://orcid.org/0000-0001-6352-8863
Jose Paolo P AguilarUST Laboratories for Vaccine Sciences, Molecular Biology, and Biotechnology, University of Santo Tomas, España Blvd., Manila 1015, Philippines.
Simone BrogiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID https://orcid.org/0000-0001-9375-6242
Chia-Hung YenGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID https://orcid.org/0000-0002-6939-5528
Kin Israel NotarteDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID https://orcid.org/0000-0002-6055-0886
Nicanor AustriacoDepartment of Biological Sciences, College of Science, University of Santo Tomas, 1015 España, Manila, Philippines.
Allan Patrick G MacabeoDepartment of Microbial Drugs, Helmholtz Center for Infection Research, Braunschweig, Inhoffenstrasse 7, D-38124 Braunschweig, Germany.ORCID https://orcid.org/0000-0001-7972-106X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytotoxic anthraquinones are natural products that modulate apoptosis and oncogenic signaling pathways. In this study, three fungal anthraquinones citreorosein (

Identifiers

PMID41939401
PMCPMC13044620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.