ArticleACS omega2026
Silk Microneedles for Targeted Epidermal Delivery of Antifreeze Proteins.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antifreeze proteins (AFPs) from cold-adapted organisms excel at modifying ice crystal growth and inhibiting ice recrystallization, making them highly attractive compounds for cryopreservation and frostbite prevention. Traditional drug delivery methods are inadequate for AFPs because their large molecular weight and charge prevent them from crossing cellular membranes and from reaching target tissues through oral, intramuscular, or intravenous routes. Transdermal microneedle (MN) patches offer a promising alternative for delivering AFPs through capillary networks just beneath the epidermis or into specific cellular compartments. However, current materials and protocols are inadequate for encapsulating, storing, and delivering functional AFPs. Here, we demonstrate that silk MN patches, manufactured using a novel heat-free fabrication method, can encapsulate and deliver AFPs into porcine skin, an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.