ArticleACS omega2026
Phase Diagram-Enabled Curcumin Isolation and Purification by Utilizing Resorcinol as Cocrystal Former and Additive.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, cocrystallization was explored as a method for purifying a compound from a complex mixture. Using the case of curcumin purification, resorcinol was selected as the additional component due to its propensity to form a cocrystal with curcumin in a mole ratio of 1:1. To enable a proper process design, a ternary phase diagram of curcumin-resorcinol-ethanol at 25 °C was constructed. However, it was found that resorcinol can only be suitably used if the curcumin content in the crude powders is at least 70 wt %, otherwise complete solubilization would occur. By taking this into account, starting from raw turmeric powders, the following operations were carried out: (1) extraction, (2) solid-liquid equilibration, and (3) two stages of cocrystal formation-dissociation. Finally, 96.06 ± 1.19 wt % curcumin purity with an overall yield of 0.26 ± 0.02 wt % was obtained. Furthermore, coformer recycling was carried out by antisolvent addition and evaporative crystallization of the mother liquor, with a recovery yield of up to 80.6 ± 1.40 wt %. Interestingly, the coformer could also be used directly as an additive to the curcumin-ethanol suspension, thereby entirely skipping the cocrystal formation-dissociation steps. Starting from raw material with 70 wt % curcumin purity, this method could produce a superior curcumin purity of 85.3 ± 2.0 wt % against 78.5 ± 1.6 wt % without any resorcinol addition, both at similar yield values.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.