ArticleACS omega2026
Mechanism of Hydrolytic Instability of ZIF‑8 in Aqueous and Buffered Media: Implications on Drug Delivery Applications.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Seeded-Growth of ZIF-8 onto Magnetic Nanoparticles: Smart Nanocarriers with Ultrahigh Drug Loading for AMF-Triggered Release.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- UiO-66 metal-organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy.FEBS open bio · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite widespread assumptions of ZIF-8 stability in aqueous media, we demonstrate that the apparent endurance of ZIF-8 is largely misconceived as thermodynamic stability rather than correctly ascribed as kinetic stability under a certain experimental setup. In unbuffered solutions, the rapid release of zinc and 2-methylimidazole ligands causes an instantaneous pH spike, which inhibits further degradation. This self-protective mechanism is, however, nullified in buffered environments, where ZIF-8 undergoes a rapid and spontaneous decomposition. Our findings ascertain a critical thermodynamic instability of ZIF-8 under physiologically relevant conditions. The findings of this investigation necessitate a fundamental re-evaluation of ZIF-8 suitability for water-based applications, particularly drug delivery. Furthermore, the insights and methodology presented herein provide a crucial framework for predicting the stability of similar metal-organic frameworks in aqueous solutions under biologically relevant conditions.
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Registered trials
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