ArticleInfection and drug resistance2026
Distribution and Antibiotic Resistance of Pathogens in Bloodstream Infections Among Elderly Patients in Sichuan Province (2020-2024).
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize the distribution and antimicrobial resistance patterns of pathogens causing bloodstream infections in elderly patients in Sichuan Province from 2020 to 2024. Methods: Non-duplicate isolates from blood of patients aged ≥65 years in 134 provincial medical institutions (113 tertiary, 21 secondary) were collected and tested per a unified protocol. Species identification and susceptibility were interpreted using CLSI M100 criteria. Data were analyzed with WHONET 5.6. The study period was stratified into pandemic (2020-2022) and post-pandemic (2023-2024) phases to assess effects on multidrug-resistant and pandrug-resistant organisms. Results: 65,603 isolates were obtained from elderly patients' blood specimens, of which 23,350 (35.6%) were Gram-positive and 42,253 (64.4%) were Gram-negative. The five most frequently detected organisms were Conclusion: From 2020 to 2024, a diverse spectrum of bacterial species was isolated from bloodstream infections in elderly patients in Sichuan Province. Following the COVID-19 pandemic, the burden of carbapenem-resistant organisms increased. Region-specific antimicrobial resistance surveillance and strengthened in-hospital infection control are essential to guide appropriate antibiotic use and to curb the spread of resistant organisms.
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