ArticleClinical, cosmetic and investigational dermatology2026
Life Events Preceding Alopecia Areata Onset-a Descriptive Retrospective Cohort Study Focusing on Strain.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients often relate preceding life events to the onset of alopecia areata (AA). This cohort study systematically examined number and type of life events together with experienced strain during two years before AA onset. Methods: The study involved 100 patients with AA who reported life events through the Social Readjustment Rating Scale (SRRS). Life event strain was examined using the Streiner model, a stress-based model in which strain is defined as undesirable, unanticipated and uncontrollable. SRRS readjustment rating and the rated strain for each life event were obtained. Percentages of strainful life events for each SRRS category were calculated. Associations between AA disease-variables, sociodemographic-variables, Beck Depression Inventory-scores and Beck Anxiety Inventory-scores were examined in relation to the number of SRRS events and the number of strainful events. Results: Total life events reported were median (range) 7.0 (0-22), almost two times higher than lifetime population studies on life events. The most experienced life events were loss of health and separation. At least one strainful life event prior to the AA onset was reported by 82% of patients. The highest strainful ratings were found in the Family and Personal categories of SRRS, such as Major change in health of a family member and Major personal injury or illness. A comparison between SRRS life events and strain ratings showed that 60% of the life events were rated higher and 35% were rated lower than the standard SRRS readjustment weight order. Conclusion: This study provides support for an inquiry into any strainful life event preceding AA onset in newly diagnosed patients with AA. Categories of highly strainful events and the importance of subjective strain are identified in patients with AA. This implies the need to address strain, which seems to be important for strain reduction thereby decreasing the burden among patients with AA.
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