ArticleFrontiers in human neuroscience2026
Genetic and environmental influence on white matter: insight from an Italian twin population study.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The heritability of white matter (WM) has been a central focus of diffusion neuroimaging and genetic research. Twin studies have reported high heritability estimates for WM integrity, primarily based on fractional anisotropy (FA). However, other diffusion tensor imaging (DTI) metrics-mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)-remain less explored. Methods: In the present twin study, we assessed WM heritability using FA, MD, AD, and RD metrics. Tract-Based Spatial Statistics was applied to DTI data from 81 healthy twin pairs (33 monozygotic, 48 dizygotic) recruited through the population-based Italian Twin Registry. Twin correlations and genetic and environmental variance components were estimated for each DTI index across brain regions. Results: Monozygotic twins exhibited higher correlations than dizygotic twins across most brain regions; however, a few regions showed an unexpected inverse pattern. Notably, while several regions demonstrated strong genetic influences, others showed no detectable genetic contribution, suggesting a substantial role for environmental factors in shaping WM characteristics in those areas. Conclusion: These findings revealed regional variability in WM heritability and challenged the assumption of uniform genetic influence, highlighting the importance of considering early environmental factors and supporting the development of more nuanced models of WM development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.