ArticleAnnals of medicine and surgery (2012)2026
Beyond the score: the imperative of comprehensive counseling in polygenic embryo screening.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Polygenic embryo screening (PES) represents an emerging advancement in assisted reproduction, enabling the estimation of polygenic risk for complex diseases and traits in embryos. While PES holds promise for reducing disease risk, it raises ethical, social, and psychological concerns, particularly regarding how prospective parents comprehend and navigate these complex choices. Current debates often emphasize the moral dimensions of PES, yet the equally crucial issue of counseling remains underexplored. Decision-making in PES is complicated by probabilistic risk scores, emotional distress, and insufficient guidance, potentially leading to misinterpretation and inequitable access to information. Establishing comprehensive, multidisciplinary counseling, integrating genetic, psychological, and ethical perspectives, is vital for informed consent and reproductive autonomy. Effective counseling must clarify uncertainties, manage expectations, and provide emotional support. Ultimately, structured, equitable, and empathetic counseling models are essential to translate the theoretical benefits of PES into ethically sound clinical practice.
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