Evidence map›Paper›PMID 41938902›Full record

ArticleAnnals of intensive care2026

Clinical outcomes of persistent sepsis-associated acute kidney injury in septic shock: a post-hoc analysis of a multicenter prospective cohort study.

Michihito Kyo, Yu Kawazoe, Takeshi Morimoto, Hitoshi Yamamura, Kyohei Miyamoto, Noriko Miyagawa, Yoshinori Ohta, Kazuya Kikutani, Shinichiro Ohshimo, Nobuyuki Hirohashi and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michihito KyoDepartment of Radiation Disaster Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yu KawazoeDepartment of Emergency and Critical Care Medicine, Sendai Medical Center, Sendai, Japan.
Takeshi MorimotoDepartment of Data Science, Hyogo Medical University, Nishinomiya, Japan.
Hitoshi YamamuraDepartment of Emergency and Critical Care Medicine, Japan Community Health Care Organization, Osaka Minato Central Hospital, Osaka, Japan.
Kyohei MiyamotoDepartment of Emergency and Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
Noriko MiyagawaDepartment of Emergency and Critical Care Medicine, Sendai Medical Center, Sendai, Japan.
Yoshinori OhtaDepartment of Emergency and Critical Care Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kazuya KikutaniDepartment of Radiation Disaster Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Shinichiro OhshimoDepartment of Radiation Disaster Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Nobuyuki HirohashiDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Nobuaki ShimeDepartment of Radiation Disaster Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sepsis-associated acute kidney injury (SA-AKI) contributes to a large morbidity and mortality burden. While emerging evidence suggests that the trajectory of SA-AKI, such as persistent SA-AKI, is associated with clinical outcomes, their association in septic shock remains unclear. Methods: In this multicenter prospective study in 20 ICUs, we investigated the incidence, clinical impact, and risk factors of persistent SA-AK in patients with septic shock requiring high-dose norepinephrine. Persistent SA-AKI was defined as an episode of AKI by KDIGO criteria lasting for at least 48 h in sepsis defined by sepsis-3 criteria. We assessed the association of persistent SA-AKI with clinical outcomes using multivariable Cox proportional hazards and logistic regression models. We also investigated risk factors for persistent SA-AKI. Results: In 257 patients with septic shock, 215 (84%) developed SA-AKI within 48 h of ICU admission, and 111 (43%) progressed to persistent SA-AKI. Patients with persistent SA-AKI had a significantly higher risk of 90-day mortality (adjusted HR, 2.75; 95% CI, 1.39-5.42; Conclusions: In patients with septic shock requiring high-dose norepinephrine, persistent SA-AKI is associated with worse clinical outcomes. These findings support the need for further research on risk stratification and targeted interventions based on the trajectory of SA-AKI. Trial registration: The study was registered on UMIN Clinical Trial Registry (UMIN000038302) on November 1, 2019.

Indexed as

Acute kidney injuryRenal failureSepsisShockVasopressor

Identifiers

PMID41938902
PMCPMC13045545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.