Evidence map›Paper›PMID 41938842›Full record

ArticleEClinicalMedicine2026

COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium.

Paolo Ivo Cavoretto, Jose Villar, Antonio Farina, Marta Fabre, Philippe Deruelle, Agustin Conde-Agudelo, Adejumoke Idowu Ayede, Ernawati Ernawati, Constanza Soto Conti, Babagana Bako and 59 more

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Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

69 authors.

Paolo Ivo CavorettoObstetrics and Gynaecology Department, IRCCS San Raffaele Hospital, Milan, Italy.
Jose VillarNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Antonio FarinaObstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Marta FabreClinical Biochemistry Department, Lozano Blesa University Hospital, Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
Philippe DeruelleDepartment of Obstetrics and Gynecology, Arnaud de Villeneuve Hospital, Montpellier, France.
Agustin Conde-AgudeloNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Adejumoke Idowu AyedeCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
Ernawati ErnawatiDepartment of Obstetrics & Gynecology, Medical Faculty, Universitas Airlangga, Surabaya, Indonesia.
Constanza Soto ContiDivision Neonatología, Hospital Materno Infantil Ramón Sarda, Buenos Aires, Argentina.
Babagana BakoDepartment of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Medical Sciences, Gombe State University, Gombe, Nigeria.
Loïc SentilhesDepartment of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France.
Satoru IkenoueDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Adele WinseyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Ken TakahashiDepartment of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
Shabina AriffDepartment of Paediatrics & Child Health, The Aga Khan University Hospital, Karachi, Pakistan.
Stephen RauchSchool of Public Health, University of California, Berkeley, CA, USA.
Gabriela TavchioskaDepartment of Pediatrics, General Hospital Borka Taleski, Prilep, Republic of North Macedonia.
Michael GravettDepartments of Obstetrics and Gynecology and of Global Health, University of Washington, Seattle, WA, USA.
Ricardo NietoDivision Neonatología, Hospital Materno Infantil Ramón Sarda, Buenos Aires, Argentina.
Federico PrefumoObstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Raffaele NapolitanoElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Francesco D'AmbrosiDepartment of Woman Child and Neonate, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Obstetrics Unit, Milan, Italy.
Laurent J SalomonHôpital Universitaire Necker-Enfants Malades, AP-HP, Université de Paris, France.
Anne Caroline BenskiHôpitaux Universitaires de Genève, Département de la Femme, de l'Enfant et de l'Adolescent, Geneva, Switzerland.
Maria José Rodriguez-SibajaInstituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico.
Roberto CasaleMaternal and Child Department, Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.
Sonia DeantoniNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Nerea MaizObstetrics Department, Hospital Universitari Vall d'Hebron, Barcelona Hospital Campus, Barcelona, Spain.
Valeria SavasiDepartment of BioMedical and Clinical Sciences, Ospedale Luigi Sacco University Hospital, University of Milan, Milan, Italy.
Irene CetinDepartment of Woman Child and Neonate, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Obstetrics Unit, Milan, Italy.
Manuela ObertoS.C. Obstetrics 2U, Sant'Anna Hospital, AOU Città della Salute e della Scienza di Torino, Italy.
Carmen VecciarelliSanatorio Otamendi, Ciudad de Buenos Aires, Argentina.
Maria Carola CapelliServicio de Neonatología del Departamento Materno Infantil, Hospital Universitario Austral, Buenos Aires, Argentina.
Becky LiuSt George's University Hospitals NHS Foundation Trust, London, UK.
Mohak MhatreTufts Medical Center, Boston, MA, USA.
Marynéa Silva do ValeUniversidade Federal do Maranhão, São Luís, Brazil.
Saturday EtukUniversity of Calabar Teaching Hospital, Calabar, Nigeria.
Hadiza Shehu GaladanciAfrica Center of Excellence for Population Health and Policy, Nigeria.
Jagjit S TejiAnn and Robert H Laurie Children's Hospital of Chicago, IL, USA.
Theresa HubkaAscension-Resurrection Medical Center, Chicago, IL, USA.
Helena SobreroCentro Hospitalario Pereira Rossell, Montevideo, Uruguay.
Guadalupe Albornoz CrespoClínica y Maternidad Suizo Argentina, Argentina.
Albertina RegoDepartamento de Pediatria, Faculdade Medicina Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Muhammad Baffah AminuDepartment of Obstetrics and Gynaecology, Abubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria.
Rachel CraikNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Mustapha Ado UsmanDepartment of Obstetrics and Gynaecology, Muhammad Abdullahi Wase Teaching Hospital, Kano State, Nigeria.
Erkan KalafatDepartment of Obstetrics and Gynecology, Koc University Hospital, Istanbul, Turkey.
Sarah Rae EasterDivision of Maternal-Fetal Medicine and Division of Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Vincent Bizor NachinabFr. Thomas Alan Rooney Memorial Hospital, Asankragwa, Ghana.
Eric BaafiHoly Family Hospital, Nkawkaw, Ghana.
Mónica SavoraniHospital de Moron, Moron, Provincia de Buenos Aires, Argentina.
Daniela CaceresHospital Julio C Perrando, Resistencia, Chaco, Argentina.
Perla K García-MayHospital Regional Lic. Adolfo López Mateos ISSSTE, Mexico City, Mexico.
Abimbola BowaleMainland Hospital Yaba Lagos, Nigeria.
Alexey KholinNational Medical Research Center for Obstetrics, Gynecology & Perinatology, Moscow, Russia.
Leila Cheikh IsmailNutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Michal LipschuetzObstetrics and Gynecology Division- Hadassah Medical Center Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Carolina GiudiceServicio de Neonatologia, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano, Buenos Aires, Argentina.
Jim ThorntonUniversity of Nottingham Medical School, Nottingham, UK.
Ramachandran ThiruvengadamTranslational Health Science and Technology Institute, Faridabad, India.
Sherief Abd-ElsalamTropical Medicine and Infectious Diseases Department, Tanta University, Tanta, Egypt.
Eduardo A DuroUniversidad de Buenos Aires, Buenos Aires, Argentina.
Valeria HernandezUniversidad Nacional de Córdoba, Argentina.
Serena GandinoNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Zulfi BhuttaCenter for Global Child Health, Hospital for Sick Children, Toronto, Canada.
Brenda EskenaziSchool of Public Health, University of California, Berkeley, CA, USA.
Stephen KennedyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Robert GunierSchool of Public Health, University of California, Berkeley, CA, USA.
Aris PapageorghiouNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We tested whether COVID-19 vaccination affects the risk of preeclampsia (PE) given the well-documented association between COVID-19 and PE, and their overlapping risk factors and pathophysiological pathways. Methods: We analysed individual level data from pregnant women prospectively enrolled from 18 countries in two consecutive cohorts between 2020 and 2022 during the COVID-19 pandemic using identical methodology. Pregnant women were recruited either with a COVID-19 diagnosis or as concomitant, consecutive, non-diagnosed controls from the same hospitals. Following vaccine availability, vaccination status was documented to define a vaccine-exposed subgroup. Multivariable logistic regression models assessed the odds of PE adjusting for confounders and cohort as a proxy for viral strain, stratifying by pre-existing morbidities and SARS-CoV-2 infection. Survival analyses estimated PE incidence according to vaccination status and pre-existing morbidities. Findings: Of 6527 pregnant women, 2166 (33.2%) were diagnosed with COVID-19 and 3753 (57.5%) were unvaccinated. Of the 2774 vaccinated women, 1795 (64.7%) received mRNA vaccines; 848 (30.6%) received the initial regimen plus a booster dose, of whom 66.6% received a booster with an mRNA vaccine. We confirmed an independent association between COVID-19 and PE (aOR: 1.45; 95% CI: 1.15-1.84), particularly in unvaccinated women (aOR: 1.78; 95% CI: 1.31-2.42). Overall, after adjusting for confounders, any vaccination gave a protective effect against PE during the index pregnancy (aOR: 0.85; 95% CI: 0.65-1.10), that was stronger with a booster dose (aOR: 0.67; 95% CI: 0.45-0.99). Among women with pre-existing morbidities who received a booster dose the odds were reduced by 58% (aOR: 0.42; 95% CI: 0.20-0.87) - an effect mainly observed in women diagnosed with COVID-19. Adjustment for study site and cohort year did not alter the magnitude of the effect. Vaccination amongst women who received a booster dose was also associated with decreased odds of maternal (aOR: 0.68; 95% CI: 0.55-0.83) and perinatal (aOR: 0.71; 95% CI: 0.54-0.95) morbidity and mortality, and preterm birth (aOR: 0.67; 95% CI: 0.53-0.85). Interpretation: COVID-19 vaccination with a booster reduces the odds of PE by 30% approaching 60% reduction among women with pre-existing morbidities. Funding: The original INTERCOVID study was supported in Oxford by the COVID-19 Research Response Fund from the University of Oxford (Ref 0009083).

Indexed as

COVID-19PreeclampsiaPregnancySARS-CoV-2Vaccine

Identifiers

PMID41938842
PMCPMC13043319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.