ArticleRegenerative biomaterials2026
Poly (d, l-lactide)/polyvinyl alcohol-based injectable microspheres with inflammation alleviation and cartilage regeneration enhancement for treatment of temporomandibular joints osteoarthritis.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Osteoarthritis (OA) is a prevalent joint disease characterizedby chronic, progressive inflammation and cartilage degeneration, for which current treatments remain limited. In this study, we propose a dual-drug delivery strategy that simultaneously suppresses inflammation and rejuvenates impaired cartilage by incorporating kartogenin (KGN) and methylprednisolone hemisuccinate (MPHS) into a single microsphere system with sequential release in the local microenvironment. To achieve coordinated dual-drug release, KGN and MPHS were loaded into the inner core and outer layer of the microspheres, respectively. Both KGN and MPHS exhibited sustained release profiles; however, MPHS showed a shorter burst-release phase than KGN due to the protective effect of the outer layer. The release of MPHS effectively suppressed interleukin-1β (IL-1β)-induced inflammation in bone marrow stromal cells (BMSCs) pellets, thereby enhancing KGN-mediated chondrogenic differentiation of BMSCs
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