ArticleNeuropsychiatric disease and treatment2026
Flaxseed Supplementation Confers Resilience to Stress-Induced Depression-Like Behaviors via GDNF Epigenetic Modulation in the Ventral Tegmental Area of Rats.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To study the improvement of dietary flaxseed supplementation on resilience to chronic stress-induced depression-like behaviors of rats and investigate whether these behavioral effects are associated with alterations in glial cell line-derived neurotrophic factor (GDNF) promoter methylation and expression in the ventral tegmental area (VTA). Methods: Forty-eight male rats were randomly grouped to chronic unpredictable stress (CUS) alone, or with flaxseeds oil (CUS/FO), or flaxseed flour (CUS/FF), flaxseed oil alone (FO), flaxseed flour alone (FF), or not any treatments (blank control, BC). FO, FF, CUS/FO, CUS/FF rats treated flaxseeds oil or flour for 5 weeks. During the second week of the 5-week period, CUS, CUS/FO, CUS/FL rats were subjected to chronic unpredictable stress for 4 weeks. Sucrose preference test (SPT) and forced swim test (FST) were used to rats' behavioral performance. The methylation levels, mRNA and protein expression of GDNF gene in the VTA were also measured after behavioral test. Results: CUS/FO rats exhibited a significantly higher sucrose preference rate (SPR) in the SPT than CUS rats ( Conclusion: Flaxseed supplementation, particularly flaxseed oil, confers resilience to chronic stress and attenuates depression-like behaviors in rat. In addition, enhancing hedonic capacity may be a key mechanism by which flaxseed promotes resilience to stress. These behavioral improvements may be mediated, at least in part, by decreased methylation of the GDNF gene promoter and subsequently up-regulation of GDNF gene expression in the VTA, highlighting an epigenetic mechanism linking dietary interventions to stress-related behavioral outcomes.
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