ArticleFrontiers in veterinary science2026
Adrenal gland adenoma with myelolipoma in a canine patient: a rare case report and diagnostic insights.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Abstract
Adrenal gland tumors are uncommon in dogs, and the simultaneous presence of epithelial and mesenchymal neoplasms within a single adrenal gland is exceptionally rare. We describe a rare case of an adrenocortical adenoma associated with a myelolipoma in a 7-year-old male Pekingese dog presented with acute abdominal pain and fever. Diagnostic imaging identified a well-defined mass in the right adrenal gland, with no evidence of vascular invasion or metastatic disease. Surgical adrenalectomy was subsequently performed. Histopathological evaluation revealed a well-circumscribed adrenocortical adenoma containing an intratumoral myelolipomatous component composed of mature adipose tissue and trilineage hematopoietic elements. Immunohistochemical analysis demonstrated Melan A positivity in the adenomatous component, while the myelolipomatous tissue showed diffuse vimentin expression and lacked Melan A immunoreactivity. The postoperative course was uneventful, and no recurrence was detected at one-year follow-up. This case underscores the diagnostic complexity of heterogeneous adrenal masses in dogs and highlights the essential role of histopathology and immunohistochemistry in the accurate identification of rare mixed adrenal lesions.
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