Evidence map›Paper›PMID 41938737›Full record

ArticleFrontiers in toxicology2026

Wood smoke particles elicit events associated with adverse effects in human lung epithelial cells.

Deedee Romo, Finnegan Friday, Michael L Armstrong, Nichole Reisdorph, Vincent Conrad, Marie J Andales, Jenny Chen, Kaila Cho, Brad L Upham, Stephen Brindley and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Deedee Romo *Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Finnegan Friday *Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Michael L ArmstrongDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Vincent ConradDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Marie J AndalesDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Jenny ChenDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Kaila ChoDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Brad L UphamDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, MI, United States.
Stephen BrindleyDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Robert C CanfieldDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Jared M BrownDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
John VolckensDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, United States.
Alison K BauerDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to wildfire smoke particulate matter (PM) is increasing around the world due to unprecedented wildfires. Numerous adverse health effects are associated with wildfire smoke PM exposures, including an increased risk of developing lung cancer in wildland firefighters. However more research is needed to fully comprehend the mechanisms involved in response to these exposures. We specifically focused on determining the effects of Douglas fir wood smoke particles (WSP) on several critical cellular events, also known to be included as hallmarks of cancer, on a bronchial epithelial cell line (BEAS-2B). The endpoints studied were pro-inflammatory cytokines/bioactive lipids and dysregulation of gap junctional intercellular communication at noncytotoxic concentrations of WSP. Polycyclic aromatic hydrocarbons (PAHs) were identified in WSP using gas chromatography-mass spectrometry (GC/MS), and WSP increased the mRNA levels of the PAH metabolizing enzymes

Indexed as

BEAS-2Bconnexingap junction intercellular communicationhuman bronchial epithelial cell lineinflammatory mediatorslungwildfirewood smoke particles

Identifiers

PMID41938737
PMCPMC13047562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.