Evidence map›Paper›PMID 41938710›Full record

ReviewGenes & diseases2026

Understanding nerve-tumor interactions: From basic biology to therapeutic innovation.

Liangzhan Sun, Xia Li, Yaxuan Wang, Jingxuan Wang, Renrui Xie, Ningyi Zhang, Zemin Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liangzhan SunPeking University Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, China.
Xia LiInstitute for Data-Driven Tumor Immunology, Chongqing Medical University, Chongqing 400016, China.
Yaxuan WangInstitute for Data-Driven Tumor Immunology, Chongqing Medical University, Chongqing 400016, China.
Jingxuan WangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Renrui XieSchool of Medicine, The Chinese University of Hong Kong-Shenzhen, Shenzhen, Guangdong 518117, China.
Ningyi ZhangSchool of Medicine, The Chinese University of Hong Kong-Shenzhen, Shenzhen, Guangdong 518117, China.
Zemin ZhangInstitute for Data-Driven Tumor Immunology, Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of nerve-tumor interactions has emerged as a rapidly advancing and interdisciplinary field with profound implications for understanding cancer progression, prognosis, and therapeutic innovation. While this area holds significant promise for transformative discoveries, the mechanisms of nerve-tumor interactions and their translation into clinical applications remain at an early stage. This review focuses on the role of peripheral nerves in non-neurogenic solid tumors, discussing the prevalence and clinical impact of nerve-tumor interactions, their underlying forms and mechanisms, advancements in research technologies, therapeutic potential, and future challenges. By synthesizing current knowledge, integrating methodologies for studying nerve-tumor interactions, and identifying critical gaps, this work aims to provide a foundational resource to guide experimental design and stimulate interest in clinical trials targeting neural influences in cancer progression.

Indexed as

Cancer cellImmune cellNerveTumorTumor microenvironment

Identifiers

PMID41938710
PMCPMC13050094

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.