ArticleFrontiers in neuroscience2026
Impact of maternal hypothyroidism during pregnancy on neonatal corpus callosum development: a transcranial ultrasound analysis.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to examine the association between maternal hypothyroidism during pregnancy and corpus callosum development in neonates. Methods: The hypothyroidism group included 64 neonates born to women diagnosed with hypothyroidism during pregnancy, while the control group comprised 101 neonates born to women without a history of hypothyroidism. Transcranial ultrasound (TCUS), together with medical imaging analysis software, was used to evaluate corpus callosum development, cerebral reactivity, and early neurodevelopmental patterns during the neonatal period. Results: Assessment of corpus callosum development across early postnatal stages showed no statistically significant differences in growth rates between preterm and full-term neonates during the first 0 to 2 weeks of life ( Conclusion: Maternal hypothyroidism during pregnancy is associated with atypical corpus callosum development and altered cerebral reactivity in neonates. These findings should be interpreted cautiously, as the observational design precludes causal inference and residual confounding cannot be excluded.
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