Evidence map›Paper›PMID 41938660›Full record

ArticleImaging neuroscience (Cambridge, Mass.)

Multimodal NIRS-MRI reveals cortical hypoperfusion, hypoxia, and mitochondrial changes in a mouse model of autoimmune inflammatory diseases.

Mada Hashem, Abbey Palset, Ying Wu, A Max Hamilton, Emily C Wuerch, V Wee Yong, Jeff F Dunn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mada HashemDepartment of Radiology, Cumming School of Medicine, University of Calgary, Alberta, Canada.ORCID https://orcid.org/0009-0009-7409-2829
Abbey PalsetDepartment of Radiology, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Ying WuDepartment of Radiology, Cumming School of Medicine, University of Calgary, Alberta, Canada.
A Max HamiltonDepartment of Radiology, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Emily C WuerchHotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada.
V Wee YongHotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-2600-3563
Jeff F DunnDepartment of Radiology, Cumming School of Medicine, University of Calgary, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal oxidative metabolism and tissue hypoxia could exacerbate multiple sclerosis. Research in both animal models and people with multiple sclerosis shows increased inflammation, reduced cerebral blood flow, damage to mitochondria, and loss of myelin. Understanding such abnormalities is crucial for developing effective treatments. In this study, we apply a multimodal imaging approach-combining near-infrared spectroscopy (NIRS) with 9.4T MRI-to investigate the cortical gray matter of the experimental autoimmune encephalomyelitis (EAE) mouse model of autoimmune inflammatory diseases. Female C57BL/6J mice (

Indexed as

cerebral blood flowhypoxiamitochondriamultimodal NIRS–MRI brain imagingmultiple sclerosisneuroinflammatory diseases

Identifiers

PMID41938660
PMCPMC13047503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.