ArticleImaging neuroscience (Cambridge, Mass.)
Age-dependent diffusion-relaxation coupling in the basal ganglia: Implications for iron deposition and microstructural dynamics.
Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigates age-related changes in diffusion-relaxation coupling within basal ganglia nuclei using a novel single-scan multi-TE diffusion-weighted imaging (SMT-DWI) approach, with a focus on microstructural alterations associated with regional iron deposition patterns during normal brain aging. Fifty-seven healthy participants (10-73 years) underwent optimized SMT-DWI at 3T, simultaneously acquiring multi-b-value (0/500/1000 s/mm²) and multi-TE (53/71/89 ms) data in 7:58 minutes (1.5 × 1.5 × 4 mm³ resolution). Apparent diffusion coefficient (ADC) and R2 maps were generated through mono-exponential fitting, with coupling quantified via TE-dependent ADC (k
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