Evidence map›Paper›PMID 41938652›Full record

ArticleCHEST critical care2026

Relationship Between ICU Delirium and Change in Quality of Life, Mood, and Cognition Over 12 Months in Survivors of Acute Respiratory Failure.

Haley Ferguson, Adriano Sanjuan, Anthony J Perkins, Maya Elias, Sophia Wang, Suneetha Naidu Mekala, Brendan Devine, Zachary Koehler, Rosalyn Chi, Sujuan Gao and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03053245 (Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03053245 nacompletednot on this map

Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors

TypeinterventionalSponsorIndiana UniversityRan2017 to 2022Enrolled503ConditionsAcute Respiratory Failure, Post-Intensive Care SyndromeArmsMobile Critical Care Program, Attention Control
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haley FergusonDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Adriano SanjuanDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Anthony J PerkinsDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Maya EliasDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Sophia WangDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Suneetha Naidu MekalaDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Brendan DevineDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Zachary KoehlerDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Rosalyn ChiDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Sujuan GaoDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Babar KhanDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Sikandar KhanDepartments of Medicine (H. F., A. S., and B. D.) and Biostatistics and Health Data Science (A. J. P. and S. G.), Indiana University School of Medicine, Indianapolis, IN; the Biobehavioral Nursing and Health Informatics (M. E.), University of Washington School of Nursing, Seattle, WA; the Department of Psychiatry (S. W.), Indiana University School of Medicine; the IU Center of Aging Research (S. N. M., B. K., and S. K.), Regenstrief Institute; and the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (Z. K., R. C., B. K., and S. K.), Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Mobile Critical Care Recovery Program (m-CCRP) for Acute Respiratory Failure (ARF) SurvivorsR01HL131730 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.2M
Reactive Oxygen Species in Respiratory Failure, Delirium, and Post-ICU Cognitive ImpairmentK76AG074925 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Sikandar Hayat Khan · 2022 to 2026
$1.1M
Academic Leadership Award for Statistical Training in Multidisciplinary Aging ResearchK07AG076659 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI SUJUAN GAO · 2022 to 2026
$777k
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit SurvivorsK23AG078448 · NIA · UNIVERSITY OF WASHINGTON · PI Maya Elias · 2023 to 2026
$597k
NHLBI NIH HHS R01 HL131730NIA NIH HHS K07 AG076659NIA NIH HHS K23 AG078448NIA NIH HHS K76 AG074925NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976
6 · The paper itself

Abstract

backgroundBoth acute respiratory failure (ARF) and ICU delirium are risk factors for postintensive care syndrome but whether quality of life (QoL) differs between delirium and subsyndromal delirium (SSD) over time is not well quantified. RESEARCH QUESTION: In ARF ICU survivors, are delirium and SSD associated with longitudinal changes in QoL, mood, and cognition up to 12 months postdischarge? STUDY DESIGN AND

methodsIn this secondary analysis, delirium (exposure variable) and SSD were assessed 2 times per day using the Richmond Agitation-Sedation Scale and Confusion Assessment Method for the ICU. QoL was the primary outcome; 36-Item Short Form Health Survey (SF-36) Physical Component Summary, SF-36 Mental Component Summary (MCS), Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores were collected at discharge, 3 months, 6 months, and 12 months. Mixed effects models were used with delirium group (delirium vs SSD vs no delirium), time, and an interaction term for group × time as independent variables.

resultsOf 456 ARF ICU survivors, 227 (50%) experienced delirium, 110 (24%) had SSD, and 121 (26%) had no delirium. The 3 groups did not significantly differ by pattern of change in SF-36 Physical Component Summary, SF-36 MCS, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, or RBANS scores over time. Delirium survivors had significantly lower SF-36 MCS scores vs SSD (predicted mean difference, -2.81; 95% CI, -5.03 to -0.59;

interpretationDelirium, rather than SSD, was associated with lower SF-36 MCS and RBANS scores up to 12 months. Further research is needed to identify ideal time points for interventions aimed at these postintensive care syndrome-related outcomes. CLINICAL

trial registrationClinicalTrials.gov; No.: NCT03053245; URL: www.clinicaltrials.gov.

Indexed as

acute respiratory failureanxietycognitioncritical caredeliriumdepressionpostintensive care syndromequality of life

Identifiers

PMID41938652
PMCPMC13048346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.