ArticleFrontiers in behavioral neuroscience2026
Investigating effects of acute severe hypoxia and p38 MAPK inhibition on boldness and anxiety-like behavior in zebrafish larvae.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Severe tissue hypoxia, resulting from cardiac dysfunction for example, is increasingly recognized as a trigger for neurobehavioral change. However, the impact of tissue hypoxia on anxiety-like behavior and disinhibition during development remains poorly understood. Zebrafish larvae provide an effective vertebrate model to evaluate how hypoxia influences behavior in early life. We assigned larvae to three groups: (1) normoxic control, (2) acute severe hypoxic exposure (HE) using cardiac dysfunction as evidence of exposure severity, or (3) HE plus 12 h exposure to 0.3 μmol AZ3 (p38 MAPK inhibitor). At one- and 2-weeks post-exposure we quantified survival, morphometrics, and behavioral measurements (emergence latency, thigmotaxis, zone occupancy, novel object approach, and velocity). Survival differed significantly among all groups (
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