Evidence map›Paper›PMID 41938644›Full record

ArticleACS catalysis2026

A Rh(II) Catalyzed Atropisomer Selective Ring Expansion of 3-Aryl Indoles to 4-Aryl Quinolines.

Mariami Basilaia, Ryan Zanolini, Nilay Kanova Dogan, Gavin Rustin, Thomas Regganie, Noah J Susskind, Jeffrey Gustafson, Yuezhi Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariami BasilaiaDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.ORCID 0000-0002-4686-0845
Ryan ZanoliniDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.ORCID 0009-0005-8047-6512
Nilay Kanova DoganDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.ORCID 0009-0001-3120-2719
Gavin RustinDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.ORCID 0000-0001-5245-7932
Thomas RegganieDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.
Noah J SusskindDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.
Jeffrey GustafsonDepartment of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook New York, 11720, United States.ORCID 0000-0001-7054-7595
Yuezhi MaoDepartment of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Dr., San Diego, California, 92182-1030, United States.ORCID 0000-0001-5362-4333

Funding

MIRA: Atropisomerism as an inspiration for drug discovery and new chemistryR35GM124637 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Jeffrey Louis Gustafson · 2017 to 2026
$3.8M
NIGMS NIH HHS R35 GM124637
6 · The paper itself

Abstract

Heterocycles containing stereogenic axes are becoming increasingly important throughout the drug discovery endeavor, and novel methodologies that provide access to pharmaceutically relevant atropisomers are in high demand. Herein, we report the rhodium (II) catalyzed atropisomer selective ring expansion of 3-aryl indoles with a-halodiazoacetates to furnish 4-aryl quinolines in good yields and enantioselectivity, with strong correlations between enantioselectivity and steric bulk observed at different positions of the substrate. Computational studies suggest that the chemistry proceeds via a Dynamic Kinetic Resolution (DKR) process wherein the catalyst reacts preferentially with the

Indexed as

Asymmetric carbene chemistryAtroposelective catalysisDynamic Kinetic ResolutionSingle-carbon insertionSkeletal editing

Identifiers

PMID41938644
PMCPMC13044781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.