ArticleFrontiers in cell and developmental biology2026
Persistent Wnt/β-catenin signaling disables soft palatogenesis and palatal osteogenesis by inducing mesenchymal condensation.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Mammalian palates are composed of the anterior hard palate and the posterior soft palate. However, the correlation of the genesis, pattern formation, and morphogenesis between the hard and soft palates remains elusive. Methods: In this study, we explicated the complicated palatal defects in Results: Immunohistochemistry showed the overlapping active canonical Wnt domain with the ectopic mesenchymal condensation, indicating that the condensation was induced by persistent canonical Wnt signaling. Discussion: These findings indicate a transition of palatal mesenchymal cells from an osteogenic fate into fibrosis commitment, along with disrupted mediolateral patterning of the palatal shelves due to persistent canonical Wnt activity. Our study provides molecular clues that fine-tuning the mesenchymal canonical Wnt activity and Wnt5a-directed cell migration correlates with the morphogenesis of hard palates and the genesis of soft palates.
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