Evidence map›Paper›PMID 41938511›Full record

ArticleInternational journal of medical sciences2026

Integrated analysis uncovers

Jiunn-Bey Pao, Yu-Mei Hsueh, Pei-Ling Chen, Tzu-Hao Huang, Chia-Yang Li, Jiun-Hung Geng, Te-Ling Lu, Chao-Yuan Huang, Shu-Pin Huang, Bo-Ying Bao

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiunn-Bey PaoDepartment of Pharmacy, Taipei City Hospital, Taipei 108, Taiwan.
Yu-Mei HsuehDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan.
Pei-Ling ChenDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Tzu-Hao HuangDepartment of Urology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Chia-Yang LiGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Jiun-Hung GengDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Te-Ling LuDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.
Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Shu-Pin HuangDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung 406, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ZZ-type zinc-finger family has emerged as an important regulator of tumorigenesis; however, its roles in renal cell carcinoma (RCC) susceptibility and prognosis are largely unexplored. This study aimed to systematically evaluate the genetic variants within this gene family to identify novel risk drivers and elucidate their downstream pathogenic networks. A total of 148 single-nucleotide polymorphisms (SNPs) were genotyped across 17 ZZ-type zinc finger genes in a cohort of 630 Taiwanese participants (312 patients with RCC and 318 healthy controls). The results were validated using pooled transcriptomic analysis of 18 independent datasets. Weighted gene co-expression network analysis (WGCNA) was used to construct tumor-specific networks and identify key driver genes. The Asian-specific variant of

Indexed as

Carcinoma, Renal CellGenetic Predisposition to DiseaseKidney NeoplasmsAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPolymorphism, Single NucleotidePrognosisTaiwanBiomarkers, Tumorgenetic variantsprognosisrenal cell carcinomaweighted gene co-expression network analysisZZ-type zinc finger family

Identifiers

PMID41938511
PMCPMC13048855

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.