Evidence map›Paper›PMID 41938501›Full record

ArticleInternational journal of medical sciences2026

Expression of ubiquitin carboxyl-terminal hydrolase isozyme L1 and chromogranin A regulated via histone-modification through Rho/ERK/NFκB signaling in oxaliplatin-resistant colorectal cancer cells.

Ko-Chao Lee, Kung-Chuan Cheng, Cheng-Yi Huang, Meng-Chiao Hsieh, Shui-Yi Tung, Yung-Yu Hsieh, Kam-Fai Lee, Chih-Chuan Teng, Hsing-Chun Kuo

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ko-Chao LeeDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Kung-Chuan ChengDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
Cheng-Yi HuangDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Meng-Chiao HsiehDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Shui-Yi TungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Yung-Yu HsiehDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Kam-Fai LeeDepartment of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chih-Chuan TengDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.
Hsing-Chun KuoDepartment of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: Resistant colorectal cancer cells (HCT-116/OxR) were established using progressive exposure to oxaliplatin (OXA). We employed siRNA, western blot, ROS assessment, apoptosis, and cell cycle assays, and animal models, to examine histone modifications regulating CHGA and UCHL1, and their impact on chemoresistance. Results: HCT-116/OxR cells displayed significantly higher OXA tolerance (elevated IC Conclusions: In this study, Rho/ERK/NFκB signaling-mediated CHGA and UCHL1 expression, which is regulated through histone modifications and affects OXA-resistant CRC EMT outcomes, was assessed, and its potential as an early detection biomarker and prognostic indicator was explored with clinical applications.

Indexed as

Colorectal NeoplasmsDrug Resistance, NeoplasmOxaliplatinUbiquitin ThiolesteraseAnimalsApoptosisEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHCT116 CellsHistonesHumansMAP Kinase Signaling SystemMiceNF-kappa BSignal TransductionHistonesNF-kappa BOxaliplatinUbiquitin ThiolesteraseUCHL1 protein, human

Identifiers

PMID41938501
PMCPMC13048854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.