ArticleKidney diseases (Basel, Switzerland)
Urinary Biomarker Profiles Define Divergent Pathways in Albuminuric and Non-Albuminuric Diabetic Kidney Disease.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Biomarkers in Diabetic Kidney Disease: Early Detection, Prognostic Assessment, and Integration with Multi-Omics Signatures.Life (Basel, Switzerland) · 2026Review
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14 authors.
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Abstract
Introduction: Diabetic kidney disease (DKD) presents with distinct phenotypes, including albuminuric (ADKD) and non-albuminuric DKD (NADKD), which are not fully distinguished by conventional clinical markers. This study aimed to evaluate urinary biomarkers indicative of nephron injury - nephrin, epidermal growth factor (EGF), vascular cell adhesion molecule-1 (VCAM-1), interleukin-18 (IL-18), and Rac-1 (Ras-related C3 botulinum toxin substrate) across various DKD phenotypes. Methods: In this cross-sectional study, 211 patients with type 2 diabetes mellitus were categorized into four groups based on estimated glomerular filtration rate (eGFR ≥ or <60 mL/min/1.73 m Results: EGF levels were significantly higher in the NADKD compared to the ADKD group. VCAM-1 was elevated in individuals with albuminuria and those with mildly reduced eGFR (<90 mL/min/1.73 m Conclusions: Higher EGF levels in the NADKD group suggest preserved tubular integrity, whereas elevated VCAM-1 in patients with albuminuria and mildly reduced eGFR indicate early vascular involvement. Positive correlations between IL-18, Rac-1, and nephrin imply a shared inflammatory and glomerular injury pathway. These results support the use of urinary biomarkers for early detection and phenotypic classification of DKD.
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