ArticleAACE endocrinology and diabetes
A Comparative Analysis of Subacute Thyroiditis: Before and After COVID-19.
Article in AACE endocrinology and diabetes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The COVID-19 infection impacts endocrine tissues, and various thyroid disorders have been reported in affected patients. Subacute thyroiditis (SAT), a self-limited inflammatory thyroid condition, is associated with viral respiratory tract infections. Studies have suggested a link between COVID-19 and SAT. Our study expands on this by examining differences in SAT severity before and after COVID-19. Methods: A retrospective cohort study analyzed SAT cases at an outpatient Ontario endocrinology clinic. Cases were identified as pre-Covid (December 2015 - April 2019) or post-Covid (December 2019 - April 2023). Patient charts were screened for diagnostic characteristics of SAT and relevant lab data, including thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). From 436 pre-Covid and 629 post-Covid cases, 32 and 37 met the inclusion criteria. Results: Our study showed no difference between incidence of SAT cases post-Covid versus pre-Covid. However, post-Covid, more patients had severe SAT, defined as values of FT4 and FT3 >30% above their upper normal range and TSH >10, (FT4 37.8 ∓ 6.7 vs 50.9 ∓ 23.5 [ Conclusion: Our study shows SAT incidence was similar pre- and post-COVID-19. Severity of the SAT disease course was amplified after the onset of the COVID-19 pandemic, with a significant elevation in FT4 and FT3 levels during hyperthyroidism and higher TSH during hypothyroidism in the post-Covid cohort.
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