ArticleJAACAP open2026
Neuroplasticity-Based Targeted Cognitive Training as Enhancement to Social Skills Program: A Randomized Controlled Trial Investigating a Novel Digital Application for Autistic Adolescents.
Article in JAACAP open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04562688 (Care Improving Cognition for ADolescents on the Autism Spectrum), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Care Improving Cognition for ADolescents on the Autism Spectrum (CICADAS)
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0 citing papers in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Objective: Few evidence-based social cognitive interventions are available to autistic youth as they navigate their complex, socially demanding teenage years. Building from pilot research using neuroplasticity-based targeted cognitive training, CICADAS (Care Improving Cognition for ADolescents on the Autism Spectrum), a digital application (app) designed to prime the brain for socio-affective learning, was developed. In a randomized active-controlled trial with 3 comparison arms, CICADAS was evaluated as a stand-alone program and as an augmentation to evidence-based PEERS (Program for the Education and Enrichment of Relationship Skills). Method: Recruiting from clinics providing PEERS, 62 adolescents (11-18 years old) with confirmed autism were enrolled. Adolescents scheduled to start PEERS were assigned using block randomization to PEERS + CICADAS (n = 22) and PEERS + Active Control (n = 21) groups. A third comparison group (n = 19) comprised adolescents who used the app as a stand-alone intervention (CICADAS only). In addition to in-app performance metrics, data were collected from social, behavioral, and cognitive assessments (self-report/parent-report measures) at preintervention (baseline), postintervention (16 weeks), and follow-up (32 weeks) sessions. Results: Significant effects of group, time, and group × time interaction were found on multiple measures collected longitudinally. For example, on the Pediatric Quality of Life Inventory, PEERS + CICADAS participants showed significant psychosocial health improvements ( Conclusion: Our data demonstrate the potential of CICADAS as a stand-alone intervention and suggest that engaging with the adaptive app (vs static active control) conferred an additional advantage to autistic teens participating in PEERS. Clinical trial registration information: Care Improving Cognition for ADolescents on the Autism Spectrum (CICADAS); https://www.clinicaltrials.gov/study/NCT04562688.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.