Evidence map›Paper›PMID 41938135›Full record

ReviewMaterials today. Bio2026

Intelligent design and application of molecular recognition hydrogels in tissue engineering.

Huaqian Xue, Liangle Liu, Ling Liu, Zhengqiu Lin, Qiancheng Gu, Lanjie Lei, Bingju Xie

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huaqian XueThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
Liangle LiuThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
Ling LiuKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Zhengqiu LinThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
Qiancheng GuKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
Bingju XieThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular recognition hydrogels are functional materials that form three-dimensional network structures through molecular-specific binding, such as antigen-antibody and ligand-receptor interactions. They exhibit excellent biocompatibility, tunable mechanical properties, and dynamic responsiveness. Furthermore, these hydrogels can simulate the microenvironment of the natural extracellular matrix and precisely regulate cell behavior, thereby broadening their application in tissue engineering. Herein, we review the definition of molecular recognition hydrogels; available crosslinking strategies, including physical, chemical, and biological crosslinking; and examples of representative systems, such as DNA hydrogels and heparin-binding protein hydrogels. We also summarize the latest research on molecular recognition hydrogels for drug delivery, biosensing, and tissue repair and regeneration (including bone, cartilage, skin, heart, and neural tissues). In addition, we discuss the challenges (such as stability and targeting) and future development directions in this field, providing new ideas for precision and personalized treatments in tissue engineering.

Indexed as

Drug deliveryHydrogelMolecular specificityTissue repair and regeneration

Identifiers

PMID41938135
PMCPMC13049675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.