Evidence map›Paper›PMID 41938122›Full record

ArticleSynthetic and systems biotechnology2026

Systematic mining and engineering of signal peptides to achieve efficient secretion of cephalosporin C acylase in

Xinyi Ren, Zhiying Yang, Siyu Chen, Chunxiang Pu, Huiying Wang, Jinlong Li, Qichen Cao, Xuyang Huang, Gang Fu, Bo Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinyi RenTianjin University of Science and Technology, Tianjin, China.
Zhiying YangTianjin University of Science and Technology, Tianjin, China.
Siyu ChenTianjin University of Science and Technology, Tianjin, China.
Chunxiang PuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Huiying WangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Jinlong LiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Qichen CaoTianjin University of Science and Technology, Tianjin, China.
Xuyang HuangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Gang FuTianjin University of Science and Technology, Tianjin, China.
Bo YuanTianjin University of Science and Technology, Tianjin, China.
Jianmei LuoTianjin University of Science and Technology, Tianjin, China.
Zhoutong SunTianjin University of Science and Technology, Tianjin, China.
Huina DongTianjin University of Science and Technology, Tianjin, China.
Dawei ZhangTianjin University of Science and Technology, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cephalosporin C acylases (CCAs) catalyze the hydrolysis of cephalosporin C to 7-aminocephalosporanic acid, a key intermediate for semisynthetic cephalosporin antibiotics. The functional secretion of heterologous CCAs in

Indexed as

Cephalosporin C acylaseEscherichia coliProtein secretionSignal peptide engineeringSignal peptide mining

Identifiers

PMID41938122
PMCPMC13049609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.