Evidence map›Paper›PMID 41938092›Full record

ArticleNeurobiology of stress2026

Microglial SIRT6 confers protection against neuroinflammation-associated depression through NRF2-HO1 signaling.

Rui Xu, Chi Zhang, Ke Chen, Yue Shi, Chun-Rong Liang, Chun-Yan Long, Hui-Yun Li, Cheng-Kang He, Ling Li

Abstract read
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In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui XuDepartment of Neurology, Xinqiao Hospital, The Army Medical University, Chongqing, 400037, China.
Chi ZhangDepartment of Medical Psychology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Ke ChenDepartment of Health Statistics, College of Preventive Medicine, The Army Medical University, Chongqing, 400038, China.
Yue ShiDepartment of Hepatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400000, China.
Chun-Rong LiangDepartment of Medical Psychology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Chun-Yan LongDepartment of Medical Psychology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Hui-Yun LiDepartment of Medical Psychology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Cheng-Kang HeShigatse Branch, Xinqiao Hospital, The Army Medical University, Shigatse, China.
Ling LiDepartment of Medical Psychology, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia-mediated neuroinflammation is widely recognized as a key contributor to various neurological diseases and psychiatric disorders, including depression; however, its underlying mechanisms remain incompletely understood. In this study, we observed a significant reduction in SIRT6 expression in neural cells, alongside a marked increase in microglial SIRT6, in a lipopolysaccharide (LPS)-induced depression model. We demonstrated that microglia-specific

Indexed as

DepressionMicroglialNRF2-HO1 signalingSIRT6

Identifiers

PMID41938092
PMCPMC13050088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.