ArticleFrontiers in aging neuroscience2026
The mechanism of external cueing interventions in improving freezing of gait in Parkinson's disease: an fNIRS study.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cortical hemodynamic responses during action observation with and without audiovisual stimuli: a randomized controlled experimental trial.Experimental brain research · 2026Trial
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5 authors.
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Abstract
Introduction: External cue interventions can effectively improve gait disturbances in patients with Parkinson's Disease (PD) and Freezing of Gait (FOG). However, the cortical mechanisms underlying cueing modulation of gait have rarely been investigated. Objectives: We aimed to compare gait performance and cerebral hemodynamic responses in patients with PD and FOG (PD-FOG) under different cueing interventions, and to further elucidate the neural mechanisms underlying the effects of different cues on gait by contrasting these findings with those of Healthy Controls (HCs). Methods: Twenty-eight PD-FOG patients and 28 HCs were enrolled. Gait parameters were measured during the walking experiment under Rhythmic Visual Cue (RVC) and Rhythmic Auditory Cue (RAC) to compare how these cues affect gait. Functional Near-infrared Spectroscopy (fNIRS) was employed to measure changes in oxyhemoglobin concentration (∆HbO Results: PD-FOG patients exhibit features including decreased gait velocity and stride length during freezing episodes. Both RVC and RAC enhance gait velocity and stride length. Conversely, the combined RVC and RAC (RVC + RAC) intervention did not produce meaningful changes in gait. Compared to HCs, PD-FOG patients show significantly lower ∆HbO Conclusion: Single visual or auditory cues can improve FOG symptoms. RVC and RAC alleviate FOG by modulating cortical activation and enhancing FC between key ROIs. The heightened connectivity among these ROIs may represent the underlying neural pathway that mediates the cue-induced alleviation of FOG.
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