ArticleFrontiers in bioengineering and biotechnology2026
A new device and method for detecting the permeability of articular cartilage.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objective: Articular cartilage relies on synovial fluid for substance exchange, with permeability being a key parameter linked to its physiological functions and degenerative disease mechanisms. Existing detection techniques are limited by detachment from physiological mechanical environments, insufficient quantification accuracy, and poor sealing. This study aimed to develop an accurate, reliable, and physiologically relevant device and method for cartilage permeability detection. Methods: Based on intra-articular convective transport and Darcy's Law, a modular testing device (permeation, pressure supply, central control modules) was fabricated to simulate the synovial fluid-cartilage-subchondral bone unit under pressure. Porcine femoral condylar cartilage samples were tested with 4 N, 8 N, 16 N (n = 6, per group) constant pressure (1800 s) using an ElectroForce 3,200 system. Permeability coefficients were calculated via Darcy's Law-derived formulas. Repeatability (single operator, fixed conditions, n = 6) and reproducibility (multiple operators, unified conditions, n = 6) were verified by CV and ANOVA. Human knee cartilage (n = 6) was used to validate practicality for clinical solutions. Data were analyzed with GraphPad Prism 9.5. Results: Friction force between the push rod and permeation tube was 2.5 N, with no leakage confirmed by eosin dye. Repeatability tests showed mean permeabilities of 1.50 × 10 Conclusion: The developed device and method address traditional limitations, featuring excellent physiological relevance, quantification accuracy, and stability. It provides a pivotal tool for studying cartilage physiology, OA pathology, optimizing repair materials and therapeutic strategies, and improving cartilage injury repair evaluation.
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